MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer’s Disease
Table 1
Expression of multiforms of MUTYH mRNA in the human hippocampus with or without AD pathology.
Transcript ID
1st exon
Splicing in exon 3
RT-PCR product (base)a
MUTYH protein isoform no.
Non-AD ()
AD ()
LRc test
Meanb
SD
Meanb
SD
value
FDR
NM_012222.3
α
1
413
1
0.022
0.065
0.175
0.257
0.096
0.612
NM_001293190.2
α
2
383
6
0.067
0.138
0.192
0.245
0.358
1.000
NM_001048171.2
α
3
380
2
0.320
0.588
0.312
0.319
0.810
1.000
NM_001293192.2
α
4
316
8
0.117
0.188
0.372
0.371
0.145
0.734
NM_001128425.2
α
5
422
5
0.155
0.252
0.145
0.104
0.783
1.000
NM_001293191.2
β
1
278
7
0.066
0.153
0.098
0.162
0.846
1.000
NM_001048174.2
β
3
245
4
0.679
1.152
0.360
0.747
0.581
1.000
NM_001293195.2
β
5
395
4
0.126
0.087
0.098
0.114
0.753
1.000
NM_001048172.2
γ
2
316
3
0.204
0.466
0.095
0.164
0.569
1.000
NM_001048173.2
γ
3
313
4
0.431
0.584
0.267
0.369
0.690
1.000
NM_001293196.2
γ
4
249
8
0.093
0.105
0.218
0.290
0.393
1.000
NM_001350650.2
α
3
380
9
0.078
0.207
0.062
0.087
0.767
1.000
NM_001350651.2
α
4
316
9
0.026
0.055
0.051
0.073
0.709
1.000
NR_146882.2
α
5
380
478 aa (52.7 kDa)
0.548
0.385
1.579
0.836
0.070
0.525
NR_146883.2
γ
3
313
363 aa (39.6 kDa)
0.372
0.669
0.308
0.870
0.860
1.000
MSTRG.709.1
α
3
380
349 aa (37.8 kDa)
0.343
0.530
0.677
0.631
0.369
1.000
MSTRG.709.2
γ
3
313
349 aa (37.8 kDa)
0.869
1.181
0.511
0.741
0.761
1.000
MSTRG.709.3
Novel 1st exon
4
NA
267 aa (29.4 kDa)
1.067
0.865
1.188
0.656
0.498
1.000
MSTRG.709.4
α
3
396
349 aa (37.8 kDa)
1.175
0.806
1.123
0.731
0.787
1.000
MSTRG.709.20
α
4
316
NC
0.673
1.035
0.645
0.483
0.835
1.000
MSTRG.709.21
Exon 3
1
NA
NC
0.611
0.717
1.379
1.483
0.179
0.806
Expression level of MUTYH at the gene level
11.684
4.594
13.615
7.139
0.005
0.103
aSizes of RT-PCR products expected in Supplementary Figure S2 are shown. bExpression levels are shown by transcripts per million. cLikelihood ratio test using the R package edgeR; bold indicates values < 0.05. RT-PCR = reverse transcription PCR; AD = Alzheimer’s disease; SD = standard deviation; FDA = false discovery rate; NA = not amplified; NC = noncoding.
