Review Article
Anesthesia-Induced Oxidative Stress: Are There Differences between Intravenous and Inhaled Anesthetics?
Table 2
Intravenous anesthetic agents investigated regarding their effect on oxidative stress.
| Study reference | Anesthetic agent | Studied population | Main effect on oxidative stress |
| [62] | Propofol | Human study | ↑ Cell viability, MMP, ↓ ROS, IL-6, and COX2 levels | [64] | Propofol | Human study | Activation of the JNK signaling pathway | [65] | Propofol, sevoflurane | Human study | ↓ ⋅OH, 8-isoprostane, micronuclei, nucleoplasmic bridges, ↑ γ-tocopherol, SOD compared with sevoflurane | [72] | Propofol, ketamine | Human study | ↓ LP, SOD, GSH-Px, ↑ TTM, TAC compared with ketamine | [82] | Propofol, midazolam | Human study | ↓ IL-6, IL-8, MDA and ↑ SOD levels compared with midazolam |
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COX: cyclooxygenase; GSH-Px: glutathione peroxidase; IL: interleukin; JNK: c-Jun N-terminal kinase; LP: lipid peroxidation; MDA: malondialdehyde; MMP: mitochondrial membrane potential; ⋅OH: hydroxyl radical; ROS: reactive oxygen species; SOD: superoxide dismutase; TAC: total antioxidant capacity; TTM: total thiol molecules.
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