Association of rs11780592 Polymorphism in the Human Soluble Epoxide Hydrolase Gene (EPHX2) with Oxidized LDL and Mortality in Patients with Diabetic Chronic Kidney Disease
Table 1
Association of rs11780592 EPHX2 polymorphism with anthropometric, clinical, and biochemical characteristics of patients with diabetic chronic kidney disease.
rs11780592 EPHX2 genotypes
AA ()
AG ()
GG ()
Age (years)
68.6 (8.1)
67.3 (9.4)
65.8 (8.8)
0.47
Gender (M/F)
34/26
17/29
3/9
0.04
BMI (kg/m2)
31.4 (5.1)
31.1 (5.7)
29.7 (4.2)
0.45
SBP (mmHg)
140.9 (18.9)
136.2 (20.8)
135.4 (22.7)
0.35
DBP (mmHg)
79.5 (9.2)
75.3 (11.0)
71.4 (10.5)
0.007
Mean BP (mmHg)
99.9 (11.1)
95.6 (12.9)
92.7 (12.8)
0.038
Duration of T2DM (years)
16.3 (7.8)
13.1 (7.2)
14.8 (8.3)
0.10
HbA1c (%)
7.5 (1.2)
7.3 (0.9)
7.7 (1.3)
0.59
Total cholesterol (mg/dL)
183.7 (47.9)
168.2 (45.6)
159.6 (30.1)
0.15
LDL cholesterol (mg/dL)
104.0 (41.3)
93.1 (35.9)
81.6 (22.0)
0.22
HDL cholesterol (mg/dL)
44.8 (11.9)
44.5 (11.9)
52.1 (19.3)
0.45
Triglycerides (mg/dL)
157.5 (66-450)
141.5 (52-551)
93.0 (69-315)
0.12
History of CV disease (%)
70
74
58.3
0.57
CRP (mg/dL)
0.25 (0-11)
0.20 (0-4)
0.20 (0-4.5)
0.72
eGFR (mL/min/1.73 m2)
43.6 (30.0)
49.5 (34.9)
60.9 (34.2)
0.27
UACR (mg/g)
66 (3-7000)
35.5 (7-2600)
20.3 (2.4-250)
0.046
Mean cIMT (mm)
0.94 (0.55-1.76)
0.89 (0.55-1.78)
0.83 (0.56-0.95)
0.031
ox-LDL (U/L)
68.3 (17.9-123.4)
53.1 (22.0-83.4)
52.9 (22.9-92.2)
0.003
values of Mann–Whitney, -test, or chi-square test for differences of variables among rs11780592 EPHX2 genotypes. BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; mean BP: mean blood pressure; T2DM: type 2 diabetes mellitus; HbA1c: glycated hemoglobin A1c; LDL: low-density lipoprotein; HDL: high-density lipoprotein; CV: cardiovascular; CRP: C-reactive protein; eGFR: estimated glomerular filtration rate; UACR: urinary albumin-creatinine ratio; cIMT: carotid intima-media thickness; ox-LDL: oxidized low-density lipoprotein.
