Nrf2-ARE Signaling Partially Attenuates Lipopolysaccharide-Induced Mammary Lesions via Regulation of Oxidative and Organelle Stresses but Not Inflammatory Response in Mice

Figure 1

Effects of Nrf2 genotype on lactation performance and expression of milk protein genes in mice. Effects of Nrf2 genotype on (a) milk production on the 6th day to 11th day of lactation (), the concentrations of (b) milk triglyceride, (c) lactose, and (d) milk protein on day 12 in lactation (), and relative mRNA abundance of (e) Csn1s1, (f) Csn1s2, (g) Csn2, and (h) Csn3 in the mammary glands of WT, Nrf2(+/-), and Nrf2(-/-) mice treated with either LPS or PBS (). In all panels, test was used to determine the differences between LPS and PBS treatments. ANOVA followed by Tukey’s multiple comparison was used to determine the differences among three genotypes of mice. Data represent . All data marked with represent a significant difference ().

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