Differential ROS-Mediated Phosphorylation of Drp1 in Mitochondrial Fragmentation Induced by Distinct Cell Death Conditions in Cerebellar Granule Neurons

<div>ROS levels induced by cell death conditions. The levels of mitochondrial and cytoplasmic ROS were measured at different times after potassium deprivation (K5) or staurosporine (ST) treatment. (a) CGN stained with MitoTracker red were imaged after 10 minutes to determine the mtROS levels under control (K25), K5, and ST treatments. The graphs show mitochondrial ROS production measured as indicated in Materials and Methods. (b) Cytoplasmic ROS were determined with DHE staining under control conditions (K25) or after 45 min and 5 h of K5 and ST treatment. The graphs show cytoplasmic ROS production measured as indicated in Materials and Methods. 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Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: Differential ROS-Mediated Phosphorylation of Drp1 in Mitochondrial Fragmentation Induced by Distinct Cell Death Conditions in Cerebellar Granule Neurons 

Figure 1 | Differential ROS-Mediated Phosphorylation of Drp1 in Mitochondrial Fragmentation Induced by Distinct Cell Death Conditions in Cerebellar Granule Neurons 