Research Article

Sea Cucumber-Derived Peptides Alleviate Oxidative Stress in Neuroblastoma Cells and Improve Survival in C. elegans Exposed to Neurotoxic Paraquat

Figure 7

Sea cucumber-derived peptides improve the survival of C. elegans exposed to paraquat. Synchronized wild-type L1 nematodes were fed with E. coli NA22 and incubated for 42 h. The L4 nematodes were then washed and transferred to 96-well plates (15-20 nematodes per well; >100 nematodes for each treatment) containing E. coli NA22 () and peptide samples. After 24 h, the nematodes were exposed to 100 mM paraquat and the numbers of live nematodes were scored under a light microscope every 12 h. Representative Kaplan-Meier survival curves are shown for the nematodes treated with or without indicated concentrations of peptide samples TP-WW-620 (a), TP-WW-621 (b), and TP-WW-623 (c). Tables on the right panel show the quantification of the survival time of paraquat-intoxicated C. elegans at different conditions.
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