Research Article

Noninvasive Analysis Using Data-Independent Acquisition Mass Spectrometry: New Epidermal Proteins That Reveal Sex Differences in the Aging Process

Table 2

Functional role of the 21 proteins.

Protein IDUniProtGene symbolFull nameFunction

HBBP68871HBBHemoglobin subunit betaThis protein includes iron ion binding and oxygen binding
HBAP69905HBA1, HBA2Hemoglobin subunit alphaInvolved in oxygen transport from the lung to the various peripheral tissues
APOA2P02652APOA2Apolipoprotein A-IIMay stabilize the HDL (high-density lipoprotein) structure by its association with lipids and affect the HDL metabolism
VAT1Q99536VAT1Synaptic vesicle membrane proteinPossesses ATPase activity (by similarity) and plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms
LG3BPQ08380LGALS3BPGalectin-3-binding proteinPromotes integrin-mediated cell adhesion and may stimulate host defense against viruses and tumor cells
KRT35Q92764KRT35Keratin, type I cuticular Ha5A member of the keratin gene family
ABRX2Q15018ABRAXAS2/FAM175BBRISC complex subunit Abraxas 2Required for normal induction of p53/TP53 in response to DNA damage
BAFO75531BANF1Barrier-to-autointegration factorPlays fundamental roles in nuclear assembly, chromatin organization, gene expression, and gonad development
G3PP04406GAPDHGlyceraldehyde-3-phosphate dehydrogenaseThe product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism
APOA1P02647APOA1Apolipoprotein A-IThis protein is associated with the transport of cholesterol and the major protein component of high-density lipoprotein (HDL)
HPTP00738HPHaptoglobinThis protein produces haptoglobin, which encodes a protein with antimicrobial activity against bacteria
CLUSP10909CLUClusterinThis protein is involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders
A1AG1P02763ORM1Alpha-1-acid glycoprotein 1This protein is classified as an acute-phase reactant and may be involved in aspects of immunosuppression
A2MGP01023A2MAlpha-2-macroglobulinThis gene can inhibit inflammatory cytokines and thus disrupts inflammatory cascades
CYTCP01034CST3Cystatin-CThis protein was shown to have an antimicrobial function
FIBGP02679FGGFibrinogen gamma chainThe protein encoded by this gene is the gamma component of fibrinogen
CERUP00450CPCeruloplasminA glycoprotein with ferroxidase activity
FIBAP02671FGAFibrinogen alpha chainThis gene encodes the alpha subunit of the coagulation factor fibrinogen
ANT3P01008SERPINC1Antithrombin-IIIA member of the serpin superfamily and a plasma protease inhibitor
FIBBP02675FGBFibrinogen beta chainThe protein encoded by this gene is the beta component of fibrinogen
VTDBP02774GCVitamin D-binding proteinInvolved in vitamin D transport and storage and scavenging of extracellular G-actin