Synthesis and Biological Screening of New 4-Hydroxycoumarin Derivatives and Their Palladium(II) Complexes

Figure 6

Quality of the Partial least square regression (PLSR) model describing the dependence of the cytotoxic effects of the investigated compounds (AHC and complexes C1 and C2) on the activity of the antioxidative defense system enzymes (GST, GR, MnSOD, CuZnSOD, with (black bars) and without (grey bars) CC1 and CC2 observations) present in a healthy fibroblast cell line (FAHC, FC1, and FC2, respectively) and pancreatic carcinoma cell line (CAHC, CC1, and CC2, respectively) (a). PLSR standardized regression coefficients. The bars indicate 95% confidence intervals based on jackknifing. Bar chart of the standardized residuals (b).

(a)

(b)