Hydrogen Sulfide Is a Regulator of Hemoglobin Oxygen-Carrying Capacity via Controlling 2,3-BPG Production in Erythrocytes

Figure 9

Integrated scheme of the potential mechanisms underlying H₂S modulating 2,3-BPG and Hb-O₂ binding affinity under normoxia and hypoxia. H₂S suppresses translocation of Hb from the cytosol to the membrane and in turn promotes BPGM anchoring to the membrane and thereby prevents an increase in 2,3-BPG levels in normoxia. During hypoxia, the decreased H₂S level promotes Hb anchoring to the membrane and BPGM release to the cytosol from the membrane, eventually resulting in an increase in 2,3-BPG production in erythrocytes.