Green Tea (Camellia sinensis) Extract Increased Topoisomerase IIβ, Improved Antioxidant Defense, and Attenuated Cardiac Remodeling in an Acute Doxorubicin Toxicity Model

Table 3

Echocardiography forty-eight hours after doxorubicin injection.

	C ()	GT ()	D ()	DGT ()
HR (bpm)					0,02	0,39	<0,001
LVDD/c (mm)					0,55	0,69	0,29
LVSD/c (mm)					0,94	0,28	0,39
PWT/c (mm/g)					0,01	0,006	0,58
RWT					0,03	0,08	0,93
LA/c (mm/g)					0,004	0,93	0,01
LA/AO (mm)					0,26	0,22	0,27
(cm/s)					0,05	0,03	<0,001
(cm/s)					0,44	0,65	0,001
					0,07	0,02	0,09
IRTc (m/s)					0,60	0,30	0,35
SF					0,72	0,24	0,74
LVMI					0,37	0,19	0,35

Groups: C: control; GT: green tea; D: doxorubicin; DGT: doxorubicin+green tea. HR: heart rate in beats per minute; LVDD/c: left ventricular diastolic diameter corrected for body weight; LVSD/c: left ventricular systolic diameter corrected for body weight; PWT: posterior wall thickness; LA/c: left atrium diameter corrected for body weight; LA/AO: left atrium diameter corrected for aorta; : wave ratio (represents the peak velocity of transmitral flow during atrial contraction); : wave ratio (represents the peak velocity of early ventricular filling); IRTc: isovolumetric relaxation time; SF: shortening fraction. Values are expressed in . value: two-way ANOVA. : value of interaction; : value of green tea; : value of doxorubicin. When we observed the interaction between factors doxorubicin and green tea, we considered . HR: , , and . PWT/c: . LA/c: , . RWT: . Comparisons without interaction: a wave and : , and waves: .