Green Tea (Camellia sinensis) Extract Increased Topoisomerase IIβ, Improved Antioxidant Defense, and Attenuated Cardiac Remodeling in an Acute Doxorubicin Toxicity Model

Table 5

Cardiac energy metabolism forty-eight hours after doxorubicin injection.

	C ()	GT ()	D ()	DGT ()
PFK (nmol/g tissue)					<0,001	0,23	0,003
LDH (nmol/mg tissue)					<0,001	<0,001	<0,001
PDH (nmol/g tissue)					0,46	0,10	0,42
CS (nmol/mg tissue)					0,08	0,46	<0,001
3-OHADH (nmol/mg tissue)					<0,001	0,55	<0,001
Complex I (nmol/mg tissue)					0,19	0,55	<0,001
Complex II (nmol/mg tissue)					0,26	0,91	<0,001
ATPs (nmol/mg tissue)					0,03	0,63	<0,001

Groups: C: control; GT: green tea; D: doxorubicin; DGT: doxorubicin+green tea. PFK: phosphofructokinase; LDH: lactate dehydrogenase; PDH: pyruvate dehydrogenase; CS: citrate synthase; β-OHADH: L-3-hydroxyacyl CoA dehydrogenase; complex I (NADH dehydrogenase): nicotinamide adenine nucleotide dehydrogenase; complex II: succinate oxide reductase; ATPs: adenosine triphosphate synthase. Values are expressed in . value: two-way ANOVA. : value of interaction; : value of green tea; : value of doxorubicin. When we observed the interaction between factors (), we compared the groups. PFK: , , and ; LDH: , , and ; β-OHADH: , , and ; ATPs: , . Comparisons without interactions: CS, complex I, complex II: .