Protective Effects of the Soluble Receptor for Advanced Glycation End-Products on Pyroptosis during Myocardial Ischemia-Reperfusion

Figure 1

Effects of sRAGE on cardiac function and infarction size following myocardial ischemia-reperfusion in mice. (a) Representative M-mode echocardiography images of the long axis after ischemia for 30 minutes and reperfusion for 24 hours in mice. (b) Quantification of the left ventricular cardiac output (ml/min) of each group. (c) Quantification of the left ventricular stroke volume (μl) of each group. (d) Quantification of the left ventricular ejection fraction (%) of each group. (e) Quantification of the left ventricular fractional shortening (%) of each group. (f) Heart rate (BPM) value of each group. (g) TTC staining pictures of the heart after I/R or sham operation. (h) Infarction area/total area of the sagittal plane of the left ventricle (%) of each group. Data are expressed as the ( mice per group). ; ; ; ns: no significance.

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