Oxidative Stress Markers among Obstructive Sleep Apnea Patients

Table 1

Characteristics of oxidative stress markers in obstructive sleep apnea (OSA) patients.

Author	Study population	Marker	Outcome
Volná J. et al. 2011 [24]	51 men divided into groups according to AHI values	hsCRP; sRAGE; PAPP-A	(i) Positive correlation between AHI, ODI, %, and hsCRP levels (); (ii) Significant difference between hsCRP levels in severe OSA () compared to healthy individuals () (); (iii) Negative correlation between sRAGE and AHI () and between sRAGE and ODI (); (iv) No correlation between OSA parameters and PAPP-A levels
Cengiz A. et al. 2018 [34]	44 OSA; 44 control group	PAPP-A	(i) PAPP-A levels significantly higher in OSA, particularly in patients with moderate severity, compared to the control group (); (ii) Negative correlation between AHI and PAPP-A; (iii) Positive correlation between minimum and mean oxygen levels at night and PAPP-A
Wysocka E. et al. 2008 [35]	41 OSA; 39 control group	SOD	(i) Decreased activity of SOD in OSA compared to controls, particularly in those with moderate to severe severity ()
Bauça J. et al. 2017 [39]	62 OSA; 52 control group	cfDNA	(i) Increased concentration of dsDNA in OSA compared to controls ()
Ye L. et al. 2010 [40]	127 OSA (43 mild, 39 moderate, and 45 severe); 52 control group	cfDNA	(i) Positive correlation between level of cfDNA and AHI and ODI; (ii) Linear correlation between cfDNA concentration and severity of OSA
Yamauchi M. et al. 2005 [41]	75 OSA (17 nonsevere [], 58 severe []	8-OHdG	(i) Urinary excretion of 8-OHdG higher in severe OSA (); (ii) Positive correlation between 8-OHdG urinary excretion and AHI, ODI, and %
Jordan W. et al. 2006 [42]	25 OSA (20 moderate to severe, 5 UARS or mild OSA)	8-OHdG	(i) 8-OHdG concentration slightly higher in patients with moderate to severe OSA (NS)
Tóthová L. et al. 2019 [46]	24 OSA ()	AOPP	(i) Salivary AOPP concentrations higher in the morning compared to evening ()
Yağmur A. et al. 2020 [47]	125 OSA (32 mild, 34 moderate, 59 severe); 40 control group	AOPP	(i) Higher levels of AOPP in severe and moderate OSA subjects compared to mild OSA subjects and healthy controls (); (ii) Positive correlation between AOPP blood concentration and AHI, %, and ODI ()
Mancuso M. et al. 2012 [48]	41 OSA (7 mild, 15 moderate, and 19 severe); 32 control group	AOPP	(i) No correlation between AOPP levels and AHI
Hopps E. et al. 2014 [49]	48 OSA (21 low [], 27 high [])	TBARS	(i) Positive correlation between AHI, ODI, and TBARS concentration ()
Cherneva R. et al. 2017 [51]	86 OSA (); 45 control group	8-Isoprostane	(i) Higher urinary excretion in OSA patients compared to controls ()
Cai W. et al. 2015 [55]	139 OSA (46 with , 46 with , 47 with )	sRAGE; esRAGE	(i) Negative correlation between sRAGE and esRAGE expression and AHI ()
Guo Q. et al. 2013 [57]	54 OSA (14 mild, 11 moderate, and 29 severe)	Trx	(i) Positive correlation between AHI and Trx concentration ()