Research Article
Resveratrol Prevents Right Ventricle Dysfunction, Calcium Mishandling, and Energetic Failure via SIRT3 Stimulation in Pulmonary Arterial Hypertension
Figure 2
Characterization of mitochondrial function from RV. Representative images (a) and pooled data (b) from in isolated RV myocytes (CTRL: cells and 3 animals; PAH: cells and 3 animals; PAH+RES: cells and 2 animals). Mitochondrial respiratory states (c, d) and respiratory control ratio (e) of isolated mitochondria preparations (CTRL: , PAH: , PAH+RES: ). (f) CRC from isolated mitochondria, in left image each arrow represents a 10 nmol CaCl2 bolus (CTRL: , PAH: , PAH+RES: ; a vs. PAH, calculated by a 2-tailed -test). CTRL: control; PAH: pulmonary arterial hypertension; PAH+RES: PAH treated with resveratrol. All data are presented as the . vs. CTRL; a vs. PAH, calculated by 1-way ANOVA.
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