The DNA Repair Enzyme XPD Is Partially Regulated by PI3K/AKT Signaling in the Context of Bupivacaine-Mediated Neuronal DNA Damage
The expression of DNA damage repair genes was determined with a cDNA plate array after SH-SY5Y cells were exposed to bupivacaine. As shown in (a), a indicates that the expression of the indicated gene was upregulated in the bupivacaine (Bup) group compared with the control (C) group, and a indicates that the expression of the gene was downregulated. A ratio greater than 1 or less than -1 indicated that there was a one order of magnitude difference. A ratio greater than 2 or less than -2 indicated that there were two orders of magnitude difference. A heatmap of the 21 DNA repair proteins is shown in (b). Each column represents a sample (control group: Con1~3; bupivacaine group: Bup1~3), and each row represents one of the DNA repair proteins. The cDNA levels of the DNA repair genes are indicated by the different colors, with the color changing from green to red with increasing expression.
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