The DNA Repair Enzyme XPD Is Partially Regulated by PI3K/AKT Signaling in the Context of Bupivacaine-Mediated Neuronal DNA Damage

Figure 7

Graphical abstract. Bupivacaine may cause neuronal oxidative DNA damage. Damaged DNA activates a largely unknown repair mechanism. Our study showed that XPD is closely involved in repairing bupivacaine-induced oxidative DNA damage in neurons. Notably, XPD may be partially regulated by the PI3K/AKT pathway.