DNA-Aptamer Raised against Receptor for Advanced Glycation End Products Improves Survival Rate in Septic Mice
Table 2
Blood gas, electrolytes, and biochemical parameters.
Characteristics
8-week-old mice
Control
LPS+vehicle
LPS+control-aptamer
LPS+RAGE-aptamer
Number
9
9
9
9
PaO2 (Torr)
83.7 (10.5)
154.9 (34.3)##
145.8 (32.6)##
115.0 (35.7)
PaCO2 (Torr)
31.9 (3.5)
34.1 (8.9)
34.4 (6.3)
35.6 (6.9)
HCO3- (mmol/l)
17.6 (0.9)
10.3 (1.7)##
10.7 (1.4)##
12.4 (0.9)
pH
7.32 (0.02)
7.06 (0.05)##
7.08 (0.05)##
7.14 (0.03)
Base excess (mEq/l)
-8.9 (1.2)
-19.9 (3.2)##
-19.3 (2.5)##
-16.2 (1.5)
Lactate (mmol/l)
1.7 (0.2)
3.6 (0.8)##
3.6 (0.9)##
2.2 (0.4)
Anion gap
21.7 (3.0)
34.1 (2.3)##
29.6 (2.2)##,†
24.2 (2.9)
Sodium (mEq/l)
149.2 (2.3)
152.0 (5.8)
150.6 (3.0)
149.6 (1.8)
Potassium (mEq/l)
4.7 (0.5)
6.1 (0.8)
6.0 (0.9)
6.4 (1.2)
Chloride (mEq/l)
109.9 (3.5)
107.6 (4.5)
110.2 (2.6)
112.9 (3.5)
Number
7
7
7
7
RBC (×109/l)
10.4 (0.4)
11.5 (0.4)##
11.2 (1.0)##
11.0 (0.3)
WBC (×109/l)
4.4 (1.6)
2.3 (0.6)##
2.1 (0.8)##
1.7 (0.6)
Hemoglobin (mg/dl)
15.4 (1.0)
17.4 (0.7)##
17.3 (1.4)##
16.4 (0.4)
Platelets (106/mm3)
39.0 (5.3)
20.7 (2.1)##
20.0 (4.5)##
27.7 (5.8)
BUN (mg/dl)
23.1 (1.3)
60.2 (5.9)##
65.7 (6.3)##
33.9 (13.3)
Creatinine (mg/dl)
0.26 (0.06)
0.70 (0.23)#
0.73 (0.27)#
0.32 (0.11)
AST (U/l)
38.1 (4.0)
165.6 (59.8)##
180.9 (55.1)##
89.7 (26.6)
ALT (U/l)
58.7 (18.8)
123.0 (10.6)##
143.0 (25.2)##
77.1 (29.7)
LDH (U/l)
1201.7 (561.7)
1583.4 (1028.9)
1249.1 (326.6)
1088.0 (398.4)
Data are presented as mean (SD). # and ## compared with control mice, respectively. and compared with mice that received LPS+control-aptamer, respectively. † compared with mice that received LPS+vehicle. RBC: red blood cells; WBC: white blood cells; BUN: blood urea nitrogen; AST: aspartate aminotransferase; ALT: alanine aminotransferase; LDH: lactate dehydrogenase.
