Exosomal lncRNA PVT1/VEGFA Axis Promotes Colon Cancer Metastasis and Stemness by Downregulation of Tumor Suppressor miR-152-3p

Figure 3

M-exo promoted tumor growth and distant metastasis in the PDX mouse model. (a) PDX mice () were divided into the following groups: control, M-exo, and P-exo. The M-exo group showed a higher tumor volume and weight (week 4) than did control and P-exo groups. Distant (b) lung and (c) lymph node metastasis analysis. Lesions in the lungs from all the three groups were examined and counted. The M-exo group exhibited the highest number of lung lesions, followed by P-exo and control groups. (d) Comparative analysis of tumorsphere-forming ability. Tumor samples harvested from the M-exo group showed a higher number of spheres; no significant difference in the number of spheres was observed between the P-exo and control groups. Mice inoculated with cells cocultured with exosomes derived from the serum of healthy individuals served as control. ; ; .

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