Research Article

TRPV1 Channel Activated by the PGE2/EP4 Pathway Mediates Spinal Hypersensitivity in a Mouse Model of Vertebral Endplate Degeneration

Figure 2

Spinal hypersensitivity increased in LSI mice. (a) Pressure tolerance was determined by a vocalization threshold in the LSI or sham group. (b–d) Voluntary and spontaneous activity was evaluated by three indicators including (b) distance traveled, (c) active time per 24 h, and (d) maximum speed of movement. (e, f) The PWF in response to the von Frey test in the LSI or sham group. vs. sham group at the corresponding time points. per group.
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