BTK Promotes Atherosclerosis by Regulating Oxidative Stress, Mitochondrial Injury, and ER Stress of Macrophages

Figure 2

BTK was determined as the hub gene related to oxidative stress, ER stress, and inflammation in macrophage-induced AS. (a) The volcano plot indicated 592 upregulated DEGs and 533 downregulated DEGs. (b) The heat map and cluster analysis. (c) STRING and Cytoscape software programs were used to construct the PPI network, and we obtained 19 hub genes through the MCODE application, of which BTK had a high score. (d) By using the cytoHubba application, the hub gene network following core gene scores was built. (e) The functional clustering network from the Metascape database indicated that BTK was closely related to oxidative stress, ER stress, and inflammation.

(a)

(b)

(c)

(d)

(e)