LYAR Promotes Colorectal Cancer Progression by Upregulating <i>FSCN1</i> Expression and Fatty Acid Metabolism

<div><i>FSCN1</i> is a novel target of LYAR. (a) Heatmap representation of gene expression for <i>LYAR</i> and <i>FSCN1</i> (indicated with arrows) and selected other genes in the <i>LYAR</i> knockdown or control HCT15 cells. Color represents expression values, with green indicating low, black indicating medium, and red indicating high expression. (b) Gene Set Enrichment Analysis (GSEA) plots of RNA-Seq in <i>LYAR</i> knockdown HCT15 cells. (c) Quantitative real-time PCR analysis of <i>LYAR</i> and <i>FSCN1</i> from <i>LYAR</i> knockdown or control HCT15 cells. 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GAPDH served as the loading control. KD1 and KD2 refer to stable <i>LYAR</i> knockdown lines <i>LYAR</i>-siRNA1 and <i>LYAR</i>-siRNA2, respectively.</div>

Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: LYAR Promotes Colorectal Cancer Progression by Upregulating <i>FSCN1</i> Expression and Fatty Acid Metabolism 

Oxidative Medicine and Cellular Longevity

LYAR Promotes Colorectal Cancer Progression by Upregulating FSCN1 Expression and Fatty Acid Metabolism

Figure 3