Changes in Key Mitochondrial Lipids Accompany Mitochondrial Dysfunction and Oxidative Stress in NAFLD

Figure 4

Western diet progressively increases oxidative stress in the liver. EPR was applied to a piece of the liver for the detection of (a) oxidized state of copper (Cu²⁺) and (b) superoxide ion. All values were expressed in arbitrary units (a.u.)/a.u. of cardiolipin. Data are expressed as ; 2-way ANOVA with (b) subsequent Bonferroni or 2-way ANOVA on rank with (a) Tukey post hoc test; and versus control diet; ^$ and ^$$$ versus weeks of diet. mice per time point and condition.

(a)

(b)