The Mechanism Underlying the Extreme Sensitivity of Duck to Aflatoxin B₁

Figure 2

The possible key metabolic pathways and potential regulatory points of aflatoxin B₁ (AFB₁) in poultry (four points), modified from Murcia and Diaz (2020). ① AFB₁ is metabolized by CYPs into AFBO. ② AFBO combines with GSH to form a detoxification compound. ③ As the storage form of AFB₁, AFL can be transformed with AFB₁. ④ AFBO removes epoxidation and initially forms AFB₁-dhd, which is finally reduced to AFB₁-dialcohol under the action of AFAR.