Triptolide Induces Liver Injury by Regulating Macrophage Recruitment and Polarization via the Nrf2 Signaling Pathway

Figure 4

Effects of TP on macrophages in Nrf2^−/− mice. (a) Changes in the proportion of monocyte-derived macrophages (F4/80⁺CD11b⁺) in WT and Nrf2^−/− mice administrated with TP for 14 days (). (b) Changes in the proportion of M2 macrophages (F4/80⁺CD206⁺) in WT and Nrf2^−/− mice administrated with TP for 14 days (). (c) Changes in the proportion of M1 macrophages (F4/80⁺CD86⁺) in WT and Nrf2^−/− mice administrated with TP for 14 days (). (d) Changes in the proportion of activated macrophages (F4/80⁺CD68⁺) in WT and Nrf2^−/− mice administrated with TP for 14 days (). Data are presented as , vs. WT-TP.

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