Research Article

Triptolide Induces Liver Injury by Regulating Macrophage Recruitment and Polarization via the Nrf2 Signaling Pathway

Figure 5

Nrf2 deficiency further promotes M1 polarization in LPS-stimulated mice after TP pretreatment. (a) F4/80 Immunofluorescent staining of the liver. Data are representative of experiments (DAPI: nucleus, F4/80: macrophages). (b) Changes in the proportion of monocyte-derived macrophages (F4/80+CD11b+) in Nrf2−/− mice administrated with TP and LPS (). (c) Changes in the proportion of liver M1 (F4/80+CD86+) and M2 (F4/80+CD206+) macrophages in Nrf2−/− mice administrated with TP and LPS (). Data are presented as , and vs. WT-control.
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