Four-Octyl Itaconate Protects Chondrocytes against H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating Nrf2 Signaling

<div>OI inhibited OA progression in DMM mouse model. (a) Histological analysis was assessed by HE and safranin O staining. (b) The OARSI scores were recorded. (c) The expressions of Nrf2 and MMP-13 in cartilage samples were detected by immunohistochemistry staining. (d, e) Quantitative analysis of positive Nrf2 and MMP-13 expressions in each section. (f) Immunofluorescence staining of Nrf2 in the cartilage samples. (g) Nrf2-positive cells in total chondrocytes of the cartilage in different groups. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Four-Octyl Itaconate Protects Chondrocytes against H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating Nrf2 Signaling 

Figure 6 | Four-Octyl Itaconate Protects Chondrocytes against H2O2-Induced Oxidative Injury and Attenuates Osteoarthritis Progression by Activating Nrf2 Signaling 