A “Weird” Mitochondrial Fatty Acid Oxidation as a Metabolic “Secret” of Cancer

Figure 6

ATP-dependent mechanism for stopping combustion of pyruvate and glucose in mitochondria, mediated by high amounts of NADH. The green arrows indicated the accumulated metabolites. The red blunt ends indicate the inhibition of a particular enzyme. a-KG: a-ketoglutarate; OAA: oxaloacetate; Q: coenzyme Q10 (oxidized form); QH2: coenzyme Q10 (reduced form); PDH: pyruvate dehydrogenase; PC: pyruvate carboxylase; Succ: succinate; Succ-CoA: succinyl-CoA; VLCDH: very long-chain acyl-CoA dehydrogenase.