STAT6/VDR Axis Mitigates Lung Inflammatory Injury by Promoting Nrf2 Signaling Pathway

Figure 1

Particle caused severe oxidative injury in lung tissue. (a) Pattern of mouse model procedure. Mice received particles intratracheally at day 0 and sacrificed at 7th day. BALF and lung tissue were harvested for next analysis. (b) Representative H&E-stained lung sections (, black arrows indicated pulmonary nodule, and infiltration of inflammatory cells was magnified at right panel). (c) The protein content of BALF was measured. Results were shown as (, , Ctrl vs. particle). (d) Relative values of MDA in lung tissue from each group were measured. Results were expressed as (, , Ctrl vs. particle). (e) IHC staining of 8-oxo-dG in the lung tissue from the indicated group was performed and quantified. Representative images from each group were shown. Results were expressed as (, , Ctrl vs. particle). (f) Representative images of TUNEL assay staining in lung tissue from each group were shown.

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