Oxidative Medicine and Cellular Longevity

Review Article

Epigenetic Changes and Functions in Pneumoconiosis

Table 2

The main lncRNA changes involved in pneumoconiosis.
lncRNARegulationModelTarget gene and signal pathwayReference
PatientsIn vivoIn vitro
RatMouseMacrophageFibroblastAlveolar epithelial cell
lncRNA-ATBUp√A549, Beas-2BlncRNA-ATB adsorbed miR-200c and released ZEB1, promoting the occurrence of EMT.[99–101]
lncRNA-MALAT1UpA549, HBElncRNA-MALAT1 can promote EMT by regulating the PI3K/AKT/SNAIL-signaling pathway by targeting miR-503 and targeting PI3K and p85.[94]、 [95]
lncRNA-CHRFUpRAW264.7, THP-1 macrophagesNIH/3T3, MRC-5lncRNA-CHRF can adsorb miR-489.
(1) miR-489 inhibited the expression of MyD88, IL-1β and TGF-β1 in mice and macrophages
(2) miR-489 inhibited total SMAD3 and p-SMAD3 levels and alleviated pulmonary fibrosis in mice and fibroblasts		[92]、 [93]
lncRNA-HOTAIRUpA549, HBElncRNA-HOTAIR regulates the pulmonary inflammatory process by targeting miR-326 to regulate TNFSF14.[91]
LOC103691771Up√Rat primary lung fibroblastsLOC103691771 promotes differentiation of myofibroblasts by regulating the TGF-β–SMAD2/3 signaling pathway.[134]
LOC102549714Up√[134]
LOC102550137Up√[134]
NONRATT015512.2Up√[135]
NONRATT017365.2Up√[135]
ENSRNOT00000054583.1Up√[135]
ENSRNOT00000048692Up√[135]
ENSRNOT00000054495.1Up√[135]
NONRATT016740.2Up√[135]
NONRATT006104.2Up√[135]
NONRATT002987.2Up√[135]
NONRATT009275.2Up√[135]
ENSRNOT00000001712Up√[135]
LOC103693125Down√[134]
LOC103692016Down√[134]
NONRATT030230.2Down√[135]
NONRATT024771.2Down√[135]
NONRATT009769.2Down√[135]
NONRATT022710.2Down√[135]
NONRATT001412.2Down√[135]
NONRATT011944.2Down√[135]
NONRATT011539.2Down√[135]
ENSRNOT00000014917Down√[135]
ENSRNOT00000083823.1Down√[135]
NONRATT029573.2Down√[135]