The Gender-Specific Interaction of DVL3 and GSK3β Polymorphisms on Major Depressive Disorder Susceptibility in a Chinese Han Population: A Case-Control Study

Table 7

The gene-gene interaction models obtained by GMDR.

Locus no.	Best model	Testing accuracy (%)	CV consistency
2	DVL3(rs1709642), GSK3β (rs6438552)	52.43	7/10	0.377
3	DVL3(rs1709642), GSK3β (rs334558, rs6438552)	55.31	10/10	0.001
4	DVL3(rs1709642), GSK3β (rs334558, rs6438552, rs2199503)	54.36	10/10	0.011
5	DVL3(rs1709642, rs1969253), GSK3β (rs334558, rs6438552, rs2199503)	53.47	10/10	0.011

For SNP: 0=no risk alleles; 1=1 risk allele; 2=2 risk alleles; adjustment for age, gender, smoking, and alcohol drinking; value was yielded by the sign test; empirical value was obtained using the permutation test (1000 replication).