Exosomal miR-17-3p Alleviates Programmed Necrosis in Cardiac Ischemia/Reperfusion Injury by Regulating TIMP3 Expression

Figure 5

Exosomal miR-17-3p greatly alleviated cardiac I/R injury. (a) miR-17-3p expression was measured by qRT-PCR. (b) LVEDd, LVEDs, and EF of the left ventricle and fractional shortening (FS) at the left ventricular short axis after cardiac I/R injury were evaluated by echocardiography. (c) The effects of the exosomes and miR-17-3p inhibitor on the infarct size were determined by TTC staining.(d, e) The effect of exosomal miR-17-3p on inflammatory cell infiltration and fibrosis was investigated using H&E and Masson staining, respectively (). Data are presented as the (); ; ; .

(a)

(b)

(c)

(d)

(e)