Mitophagy: A Potential Target for Pressure Overload-Induced Cardiac Remodelling

Figure 2

Mitochondria-related damage and potential role of mitophagy in pressure overload model. More mitochondrial cristae disorders, decreased cristae density, and mitochondrial swelling appear after pressure overloaded. Mitochondrial respiration is impaired. Oxidative stress is an important mediator in the mechanism of pathological cardiac remodelling. Under pressure overload, a variety of mechanisms regulate the increase of ROS and RNS. Under pressure overload, ROS and a variety of upstream signals also lead to mtDNA damage, resulting in pathological cardiac remodelling. mtDNA damage and ROS activate mitophagy through a variety of mechanisms. Mitophagy inhibits the adverse effects of ROS and mtDNA.