Research Article

Combination of Colchicine and Ticagrelor Inhibits Carrageenan-Induced Thrombi in Mice

Figure 2

The combination of ticagrelor and colchicine inhibits carrageenan-induced thrombosis in mouse tail. (a) Experimental design: BALB/c mice in 5 groups (5/group) received the following treatment; negative control group (NC) and control group (Control): i.g. administration of PBS; Tig group: i.g. administration of ticagrelor (40 mg/day/kg bodyweight) for 4 days; Col group: i.g. administration of colchicine (0.05 mg/day/kg bodyweight) for 4 days; TC group: i.g. administration of ticagrelor and colchicine for 4 days. Mice were i.p. injected with carrageenan solution (50 mg/kg bodyweight) on day 2, except for those in the NC group. Two days after carrageenan injection, all mice were sacrificed followed by collection of blood, tail, liver, and lung samples individually; (b, c) tail from each mouse was photographed, and the representative pictures were presented (b). The thrombosis rate was calculated (c). (d, e) The cross sections of tail at different tail locations were conducted HE staining (d) and at the location of 3 cm were conducted Masson staining (e). ND: not detected; vs. NC group; ### vs. control group ().
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