Combination of Colchicine and Ticagrelor Inhibits Carrageenan-Induced Thrombi in Mice

Figure 5

Colchicine attenuates human platelet CD36, PAR4 levels, but enhances antioxidant enzyme expression. (a–d) Human platelets were pretreated with ticagrelor (10 μM), colchicine (100 ng/ml), or ticagrelor plus colchicine for 2 h at 37°C, followed by treatment with thrombin (1 U/mL) for 2 min. Expression of CD36, PAR4, CAT, GPx-1, SOD2, and GAPDH was determined by Western blot (a, c) with quantitation of band density (b, d); and vs. control; ^## and ^### vs. thrombin-treated group ().

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