Cycloastragenol Confers Cerebral Protection after Subarachnoid Hemorrhage by Suppressing Oxidative Insults and Neuroinflammation via the SIRT1 Signaling Pathway

Figure 1

Dose-response effects of CAG on SAH. (a) The chemical structure of CAG. (b) Schematic representation of the cortex area sampled for evaluation. (c) Western blot analysis for SIRT1. (d) Quantification of protein expression of SIRT1 after CAG treatment ( =6 per group). (e) Representative photomicrographs of Nissl staining. Arrows point to degenerated neurons. Scale bar =50 μm. Changes of (f) neurological deficits scores and (g) motor function after CAG treatment ( =9-10 per group). .

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