Research Article

Treatment with the Ferroptosis Inhibitor Ferrostatin-1 Attenuates Noise-Induced Hearing Loss by Suppressing Ferroptosis and Apoptosis

Figure 2

Fer-1 treatment alleviates noise-induced auditory threshold elevation and OHC loss. (a) Fer-1 treatment considerably reduces noise-induced mouse ABR threshold shifts. The data are shown as individual points and the of each group. ; ; ; ns: not significant. (b) Representative images show noise-induced OHC loss. Pictures were taken from the basal turn of the cochlea (~4.0 mm from the apex). . (c) Cochlear OHC loss assessed 14 d after noise exposure presented as a percentage. Fer-1 treatment markedly alleviated noise-induced OHC loss. ; .