Research Article

Treatment with the Ferroptosis Inhibitor Ferrostatin-1 Attenuates Noise-Induced Hearing Loss by Suppressing Ferroptosis and Apoptosis

Figure 9

Fer-1 treatment exerts protective effects against NIHL partially by suppressing ferroptosis and apoptosis. (a) The expression levels of TfR1, P53, GPX4, ACSL4, AIFM2, AIF, SOD2, and BAX in the mouse cochlea exposed to different treatment combinations. (B) Semiquantification of the gray values of the TfR1, P53, GPX4, ACSL4, AIFM2, AIF, SOD2, and BAX bands. ; ; ns: not significant. (c) HEK293 cells transfected with endogenously FLAG tagged P53 were lysed for immunoprecipitation with anti-FLAG and anti-4-HNE antibodies. (d) Ferrostatin-1 protects hearing by suppressing ferroptosis and apoptosis.
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