Association between Arsenic Level, Gene Expression in Asian Population, and In Vitro Carcinogenic Bladder Tumor

Figure 4

Arsenic-level dependent genetic variations. (a, b) PLS-DA plot showing the gene expression profile distribution of each sample between different levels of arsenic exposure (red, high; purple, medium; and green, low) for Data1 and Data2, respectively. The first two components of PLS-DA (PC1 and PC2) of gene expression profile and overall variance between the groups are displayed. Each dot represents a sample color coded by As-level. (c) Venn diagram, overlap of most significantly differentially expressed genes when comparing the low vs. high for Data1 and low-medium-high ( value ≤ 0.05) for Data2 and represented by blue (Data1) and red (Data2), respectively. The names of common genes are provided in a table (underneath). (d) Venn diagram, overlap of most significantly differentially expressed gene when compared the low vs. high for Data1 and pairwise comparison between low-medium-high with ( value ≤ 0.05) and represented as Data1 (yellow) and Data2 (blue, low vs. high; red, low vs. medium; green, medium vs. high), respectively. (e, f) Venn diagram, associated pathways for the genes identified in figure (c, d) with same classification and color coding described. The names of common genes are provided in a table (underneath). The complete lists of significant genes are provided in supplementary table-6 and table-8, and significant pathways are in supplementary table-7 and table-9.

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