Research Article

Myostatin Deficiency Enhances Antioxidant Capacity of Bovine Muscle via the SMAD-AMPK-G6PD Pathway

Figure 7

MSTN affects G6PD tyrosine phosphorylation through AMPK to improve muscle antioxidant capacity. MSTN regulates the AMPK pathway through the Smad2/3 pathway, and the upregulated AMPK activates the phosphorylation of G6PD tyrosine. The enhancement of G6PD upregulates the pentose phosphate pathway, thereby enhancing the content of nonenzymatic antioxidant GSH and improving the antioxidant capacity of muscles. In addition, the pentose phosphate pathway supplements the second stage of glycolysis to enhance its product yield.