Zingerone Inhibits the Neutrophil Extracellular Trap Formation and Protects against Sepsis via Nrf2-Mediated ROS Inhibition

<div>ZIN inhibited PMA-induced ROS production and the formation of NETs through Nrf2 pathway. (a) DCFH-DA staining and (b) SYTOX green staining of neutrophils in different groups was analyzed by flow cytometry. (c) ZIN effects on the MPO-DNA complex in neutrophil supernatant. (d) The effects of ZIN on NET production in human neutrophils stimulated with PMA for 3 hours (histone: green; dsDNA: blue) (fluorescence and light microscope, magnification ×200). 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Zingerone Inhibits the Neutrophil Extracellular Trap Formation and Protects against Sepsis via Nrf2-Mediated ROS Inhibition 