Inhibiting Microglia-Derived NLRP3 Alleviates Subependymal Edema and Cognitive Dysfunction in Posthemorrhagic Hydrocephalus after Intracerebral Hemorrhage via AMPK/Beclin-1 Pathway

Figure 1

Spatial and recognition memory and spontaneous motor behavior assessment after ICH-IVH and inhibiting NLRP3 inflammasome with MCC950. (a) Schematic diagram of the experimental design. (b) Representative movement tracks and recognition memory in the sham and MCC950 treatment or not groups at 3 days after ICH-IVH. (c) Representative swim paths during the probe trial for spatial memory showing that ICH-IVH rats with MCC950 treatment made more crossings over the former platform location and spent more swim time in the target quadrant than ICH-IVH rats, indicating spatial memory impairment improved. (d) Comparison of times crossing the former target area of different groups. (e) Comparison of latency to the platform during the 5 days of Morris water maze training. (f) Comparison of time spent in the target quadrant in the probe trial. (g) Corner tests aimed at the motor function after ICH-IVH and MCC950 treatment. (/group). Results are presented as , and versus sham group, ^## and ^# ICH-IVH group versus MCC950 group.

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