Inhibiting Microglia-Derived NLRP3 Alleviates Subependymal Edema and Cognitive Dysfunction in Posthemorrhagic Hydrocephalus after Intracerebral Hemorrhage via AMPK/Beclin-1 Pathway

Figure 2

Subependymal edema assessment after ICH-IVH mediated hydrocephalus and MCC950 treatment. (a) Representative images of T2-weighted and pseudocolor showed subependymal edema at 3 days in different groups. (b) The brain water content of different parts of brain after various treatments. (c) Quantification analysis of volumes of brain edema of subventricular zones according to MRI images. (d) HE-staining images of subventricular zones tissues showed edema and capillaries conditions (upper). . TEM images of capillaries of all 3 groups (lower). . (e) Representative images of ZO-1 expressed in capillaries (CD31). . (f) Western blots images and analysis results showed the ZO-1 expression of different groups in SVZ. Results are presented as , ns , and versus sham group, ^## and ^# ICH-IVH group versus MCC950 group.

(a)

(b)

(c)

(d)

(e)

(f)