Inhibiting Microglia-Derived NLRP3 Alleviates Subependymal Edema and Cognitive Dysfunction in Posthemorrhagic Hydrocephalus after Intracerebral Hemorrhage via AMPK/Beclin-1 Pathway

Figure 7

Schematic mechanism of NLRP3 activation in microglia/macrophages contributes to subependymal edema and neurons apoptosis by upregulating autophagy through AMPK/ULK1/Beclin-1 pathway. After ICH-IVH, rats occurred subependymal edema which contributes to cognitive dysfunction. Next, we found NLRP3 inflammasome activation in microglia/macrophage-mediated neurons excessive autophagy, and excessive autophagy caused neuron damage through the AMPK/Beclin-1 pathway. Administration NLRP3 specific inhibitor MCC950 could reduce edema in SVZ and improve neurofunction after hydrocephalus.