Pharmacological Approaches to Decelerate Aging: A Promising Path

Figure 3

Mechanistic effect of rapamycin on longevity. The antiaging effects of rapamycin are mediated by inhibition of mTORC1. Rapamycin can also inhibit mTORC2 in conditions of prolonged exposure. mTORC2 can affect mTORC1 via the AKT/TSC2/Rheb pathway. mTORC2 is involved in cell survival by affecting AKT and SKG1. mTORC2 is involved in Actin/cytoskeleton organization by affecting PKC-α. mTORC2 is involved in cell survival by affecting AKT. mTORC1 regulates autophagy via the ULK1 pathway. mTORC1 can regulate transcription and translation by affecting S6K; it can also regulate translation by affecting 4E-BP1.