Alternate-Day Ketogenic Diet Feeding Protects against Heart Failure through Preservation of Ketogenesis in the Liver

Figure 1

Continuous KD feeding failed to protect the heart against heart failure. (a) Body weight of sham and TAC mice postsurgery. (b) Food intake of sham and TAC mice. (c) Voluntary physical activity as assessed by voluntary wheel running in sham and TAC mice. (d) Echocardiography revealed that KD feeding showed no significant effects on LV systolic function in TAC mice. (e) Representative pulsed-wave Doppler (top) and tissue Doppler (bottom) tracings. The ratio between early mitral inflow velocity and mitral annular early diastolic velocity () was quantified in the right. (g) Heart weight/body weight of sham and TAC mice. (h) KD feeding failed to attenuate cardiac fibrosis in TAC mice. (i) KD feeding decreased the cross-sectional area of cardiomyocytes in TAC mice. (j) Cardiac ROS levels in sham and TAC mice. (k) Cardiac expressions of SOD2, GPX1, and catalase in sham and TAC mice. (b–k) Experiments were performed at 8 weeks postsurgery. . ; ; .

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