Research Article

Associations of the Cardiometabolic Index with the Risk of Cardiovascular Disease in Patients with Hypertension and Obstructive Sleep Apnea: Results of a Longitudinal Cohort Study

Table 2

Hazard ratios (95% CI) of cardiovascular disease, coronary heart disease, and stroke, stratified by CMI.

ExposureModel 1Model 2Model 3
(HR, 95% CI) value(HR, 95% CI) value(HR, 95% CI) value

Cardiovascular disease
Per SD increment1.48 (1.33, 1.65)<0.0011.35 (1.24, 1.47)<0.0011.31 (1.20, 1.43)<0.001
Tertiles
T1 (<0.73)ReferenceReferenceReference
T2 (≥0.73 to <1.21)1.86 (1.32, 2.63)<0.0011.70 (1.25, 2.31)<0.0011.60 (1.18, 2.16)0.003
T3 (≥1.21)2.71 (1.87, 3.92)<0.0012.39 (1.78, 3.22)<0.0012.17 (1.63, 2.90)<0.001
P for trend<0.001<0.001<0.001
Categories
T1-2 (<1.21)ReferenceReferenceReference
T3 (≥1.21)1.73 (1.33, 2.25)<0.0011.77 (1.42, 2.22)<0.0011.68 (1.35, 2.09)<0.001
Coronary heart disease
Per SD increment1.51 (1.32, 1.74)<0.0011.38 (1.24, 1.53)<0.0011.33 (1.20, 1.48)<0.001
Tertiles
T1 (<0.73)ReferenceReferenceReference
T2 (≥0.73 to <1.21)2.25 (1.43, 3.54)<0.0012.06 (1.38, 3.08)<0.0011.90 (1.28, 2.83)0.002
T3 (≥1.21)3.35 (2.07, 5.44)<0.0012.96 (2.01, 4.37)<0.0012.62 (1.79, 3.83)<0.001
P for trend<0.001<0.001<0.001
Categories
T1-2 (<1.21)ReferenceReferenceReference
T3 (≥1.21)1.85 (1.32, 2.58)<0.0011.94 (1.46, 2.57)<0.0011.81 (1.37, 2.39)<0.001
Stroke
Per SD increment1.44 (1.20, 1.72)<0.0011.31 (1.13, 1.52)<0.0011.27 (1.10, 1.47)0.001
Tertiles
T1 (<0.73)ReferenceReferenceReference
T2 (≥0.73 to <1.21)1.48 (0.86, 2.55)0.1561.30 (0.80, 2.09)0.2851.23 (0.77, 1.98)0.384
T3 (≥1.21)2.02 (1.13, 3.63)0.0181.78 (1.12, 2.82)0.0151.64 (1.05, 2.57)0.031
P for trend0.0170.0130.029
Categories
T1-2 (<1.21)ReferenceReferenceReference
T3 (≥1.21)1.54 (1.02, 2.37)0.0411.55 (1.07, 2.25)0.0221.47 (1.02, 2.12)0.039

Model 1: adjusted for age and sex. Model 2: adjusted for variables in model 1 plus drinking status, history of diabetes, smoking status, DBP, SBP, and BMI. Model 3: adjusted for all noncollinear variables. SD: standard deviation; HR: hazard ratio; CI: confidence interval. Other abbreviations appear in Table 1.