Associations of the Cardiometabolic Index with the Risk of Cardiovascular Disease in Patients with Hypertension and Obstructive Sleep Apnea: Results of a Longitudinal Cohort Study
Table 2
Hazard ratios (95% CI) of cardiovascular disease, coronary heart disease, and stroke, stratified by CMI.
Exposure
Model 1
Model 2
Model 3
(HR, 95% CI)
value
(HR, 95% CI)
value
(HR, 95% CI)
value
Cardiovascular disease
Per SD increment
1.48 (1.33, 1.65)
<0.001
1.35 (1.24, 1.47)
<0.001
1.31 (1.20, 1.43)
<0.001
Tertiles
T1 (<0.73)
Reference
Reference
Reference
T2 (≥0.73 to <1.21)
1.86 (1.32, 2.63)
<0.001
1.70 (1.25, 2.31)
<0.001
1.60 (1.18, 2.16)
0.003
T3 (≥1.21)
2.71 (1.87, 3.92)
<0.001
2.39 (1.78, 3.22)
<0.001
2.17 (1.63, 2.90)
<0.001
P for trend
<0.001
<0.001
<0.001
Categories
T1-2 (<1.21)
Reference
Reference
Reference
T3 (≥1.21)
1.73 (1.33, 2.25)
<0.001
1.77 (1.42, 2.22)
<0.001
1.68 (1.35, 2.09)
<0.001
Coronary heart disease
Per SD increment
1.51 (1.32, 1.74)
<0.001
1.38 (1.24, 1.53)
<0.001
1.33 (1.20, 1.48)
<0.001
Tertiles
T1 (<0.73)
Reference
Reference
Reference
T2 (≥0.73 to <1.21)
2.25 (1.43, 3.54)
<0.001
2.06 (1.38, 3.08)
<0.001
1.90 (1.28, 2.83)
0.002
T3 (≥1.21)
3.35 (2.07, 5.44)
<0.001
2.96 (2.01, 4.37)
<0.001
2.62 (1.79, 3.83)
<0.001
P for trend
<0.001
<0.001
<0.001
Categories
T1-2 (<1.21)
Reference
Reference
Reference
T3 (≥1.21)
1.85 (1.32, 2.58)
<0.001
1.94 (1.46, 2.57)
<0.001
1.81 (1.37, 2.39)
<0.001
Stroke
Per SD increment
1.44 (1.20, 1.72)
<0.001
1.31 (1.13, 1.52)
<0.001
1.27 (1.10, 1.47)
0.001
Tertiles
T1 (<0.73)
Reference
Reference
Reference
T2 (≥0.73 to <1.21)
1.48 (0.86, 2.55)
0.156
1.30 (0.80, 2.09)
0.285
1.23 (0.77, 1.98)
0.384
T3 (≥1.21)
2.02 (1.13, 3.63)
0.018
1.78 (1.12, 2.82)
0.015
1.64 (1.05, 2.57)
0.031
P for trend
0.017
0.013
0.029
Categories
T1-2 (<1.21)
Reference
Reference
Reference
T3 (≥1.21)
1.54 (1.02, 2.37)
0.041
1.55 (1.07, 2.25)
0.022
1.47 (1.02, 2.12)
0.039
Model 1: adjusted for age and sex. Model 2: adjusted for variables in model 1 plus drinking status, history of diabetes, smoking status, DBP, SBP, and BMI. Model 3: adjusted for all noncollinear variables. SD: standard deviation; HR: hazard ratio; CI: confidence interval. Other abbreviations appear in Table 1.