Functional Evaluation of KEL as an Oncogenic Gene in the Progression of Acute Erythroleukemia

Figure 3

KEL promotes erythroid differentiation and regulates the expression of GATA1 through moderation of H3K27ac. (a) Erythroid differentiation ability induced by Hemin with different KEL level assessed by benzidine staining. (b, c) qPCR and western blot analyzing the expression change of erythroid differentiation marker (γ-globin and fut1) and TF (GATA1). (d) Positive relationship between GATA1 and KEL form TCGA. (e) The level of histone with different KEL expressions. (f) The ChIP-qPCR results suggesting most potential modification sites.

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