A New Perspective on the Treatment of Alzheimer’s Disease and Sleep Deprivation-Related Consequences: Can Curcumin Help?

Table 2

Completed clinical studies with curcumin.

Study (year)	Participants	Dose/duration	Study design
Baum et al., 2008, NCT00164749	36 participants with AD	1 g/4 g curcumin (capsules or as powder to be mixed with food)/placebo, 6 months	Double-blind, placebo controlled, randomized, pilot clinical trial
Ringman et al., 2012, NCT00099710	33 participants with wild to moderate AD	2 g/4 g curcumin C3complex/placebo, 6 months	A phase II, double-blind, placebo-controlled, randomized study
Paul H. Wand, NCT01716637	12 participants with AD	25 mg etanercept, administered weekly for 6 weeks; nutritional supplement (super biocurcumin) administered daily for 6 weeks	Open label, randomized, crossover, pilot study
Cox et al., 2015	60 healthy participants	400 mg Longvida/placebo, 1 h/3 h/4 weeks	Randomized, double-blind, placebo-controlled trial
Rainey Smith et al., 2016	96 healthy participants	1.5 g Biocurcumax/placebo, 12 months	Randomized, placebo-controlled, double-blind trial
Small et al., 2018	40 participants (nondemented)	90 mg of curcumin (Theracurmin) twice daily, 18 months	Randomized, double-blind, placebo-controlled trial