Propofol via Antioxidant Property Attenuated Hypoxia-Mediated Mitochondrial Dynamic Imbalance and Malfunction in Primary Rat Hippocampal Neurons

Figure 2

Hypoxia-mediated effects on mitochondrial abnormality were alleviated by propofol pretreatment. Hypoxia treatment for 0 h was considered as normoxic condition and served as control. “-” represents the absence of specific treatment, and “+” represents the presence of specific treatment. Data were presented as the percentage of of treated neurons compared with that of untreated control neurons, which was set as 100%, and represents the number of independent repeats. (a) 25, 50, and 100 μM propofol reversed hypoxia-mediated mitochondrial dynamic imbalance. (b) 50 and 100 μM propofol reversed hypoxia-mediated mPTP opening. (c) 50 and 100 μM propofol reversed hypoxia-mediated MMP values. (d) 50 and 100 μM propofol reversed hypoxia-mediated intracellular ATP content.

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