Review Article

The Efficacy and Safety of Chinese Herbal Medicine in the Treatment of Knee Osteoarthritis: An Updated Systematic Review and Meta-Analysis of 56 Randomized Controlled Trials

Table 3

Ingredients of CHM in the included studies.

StudyPrescription nameIngredients of herb prescriptionPreparationsQuality control

Chen 2017 [28]Sanbi Xiao granuleAngelica sinensis, Radix Paeoniae Alba, Radix Rehmanniae Recen, Ginseng, Astragalus, Achyranthes root, Eucommia ulmoidesGranuleGuangdong FDA approval number: ZB20060360
Chen 2018 [29]Danqi granuleRadix Rehmanniae Praeparata, Cornus officinalis, Rhizoma alismatis, Chinese yam, Epimedium, Paeonia suffruticosa, Tuckahoe, Barbary wolfberry fruit, Semen Cuscutae, herba Cistanche, Concha ostreaeGranuleSFDA approval number: Z20050537
Cui 2017 [31]Chaihu Jiangu decoctionRadix Bupleuri, Scutellaria baicalensis, Rhizoma Pinellinae Praeparata, Codonopsis pilosula, Cassia twig, Radix Paeoniae Alba, Rhizoma Chuanxiong, Achyranthes root, Arisaema cum bile, liquoriceDecoctionHospital preparation
Cui 2018 [30]Bushen Huoxue decoctionRadix Rehmanniae Praeparata 15 g, Epimedium 15 g, Semen Cuscutae 15 g, Angelica sinensis 10 g, Salviae miltiorrhizae 10 g, Achyranthes root 10 g, Eucommia ulmoides 10 g, Radix Dipsaci 10 g, Radix Codonopsis 15 g, Rhizoma Atractylodis macrocephalae 15 g, liquorice 6 gDecoctionHospital preparation
Dou 2015 [32]Danzi Kangxi electuaryHuman placenta, Salviae miltiorrhizae, Radix Rehmanniae Praeparata, Achyranthes root, Fructus psoraleae, Morinda officinalis, parasitic Loranthus, woodlouse, Radix Angelicae Pubescentis, Radix Paeoniae AlbaElectuaryHospital preparation
Fu 2018 [33]Duhuo Jisheng decoctionRadix Angelicae Pubescentis 15 g, parasitic Loranthus 15 g, glossy privet fruit 15 g, Semen Cuscutae 15 g, Angelica sinensis 15 g, Eucommia ulmoides 15 g, Barbary wolfberry fruit 15 g, Radix Sileris 15 g, Semen Psoraleae 15 g, Achyranthes root 15 g, peach seed 10 g, flowers carthami 10 g, Rhizoma Chuanxiong 10 g, herba Lycopi 10 g, liquorice 6 g, Asarum 3 gDecoctionHospital preparation
Guo 2019 [34]Duhuo Jisheng decoctionRadix Angelicae Pubescentis 15 g, parasitic Loranthus 15 g, glossy privet fruit 15 g, Semen Cuscutae 15 g, Angelica sinensis 15 g, Eucommia ulmoides 15 g, Barbary wolfberry fruit 15 g, Radix Sileris 15 g, Semen Psoraleae 15 g, Achyranthes root 15 g, peach seed 10 g, flowers carthami 10 g, Rhizoma Chuanxiong 10 g, herba Lycopi 10 g, liquorice 6 g, Asarum 3 gDecoctionHospital preparation
He 2019 [35]Shuanggu Sanzi capsuleWoodlouse, Rhizoma Drynariae, Pyritum, Astragalus, Angelica sinensis, Resina Draconis, Rheum officinale, olibanum, myrrh, Rhizoma Cibotii, Semen Allii Tuberosi, muskmelon seed, cucumber seedCapsuleSFDA approval number: B20020788
Hong 2013 [36]Qufeng Jiangu decoctionRhizoma seu Radix Notopterygii 30 g, Caulis Spatholobi 30 g, Radix Cynanchi Panicullati 30 g, Rhizoma Chuanxiong 15 g, Rhizoma Curcumae 15 g, Radix Curcumae 15 g, Rhizoma Drynariae 15 g, obscured homalomena rhizome 15 g, Berba Aristolochiae Mollissimae 15 g, liquorice 6 g, Pericarpium Citri Reticulatae 6 gDecoctionHospital preparation
Hu 2012 [37]Bushen Zhuangu decoctionRadix Rehmanniae Praeparata 15 g, Epimedium 15 g, Semen Cuscutae 15 g, Angelica sinensis 10 g, Salviae miltiorrhizae 10 g, Achyranthes root 10 g, Eucommia ulmoides 10 g, Radix Dipsaci 10 g, Radix Codonopsis 15 g, Rhizoma Atractylodis macrocephalae 15 g, liquorice 6 gDecoctionHospital preparation
Huang 2015 [38]Bushen Guangjie Huoluo PulvisSemen Cuscutae 10 g, Rhizoma Atractylodis macrocephalae 20 g, Morinda officinalis 20 g, Notoginseng Radix 15 g, Radix Curcumae Longae 15 g, Achyranthes root 30 g, Radix Arnebiae seu Lithospermi 15 g, Rhizoma Alismatis 20 g, desert Cistanche 20 g, Radix Sileris 20 g, liquorice 5 g, Rhizoma Chuanxiong 20 g, Radix Arnebiae seu Lithospermi 15 g, cowherb seed 15 gPulvisHospital preparation
Jiang 2009 [39]Bushen Huoxue decoctionRadix Rehmanniae Praeparata 15 g, Epimedium 15 g, Semen Cuscutae 15 g, Angelica sinensis 10 g, Salviae miltiorrhizae 10 g, Achyranthes root 10 g, Eucommia ulmoides 10 g, Radix Dipsaci 10 g, Radix Codonopsis 15 g, Rhizoma Atractylodis macrocephalae 15 g, liquorice 6 gDecoctionHospital preparation
Li 2018 [40]Duhuo Jisheng decoctionRadix Angelicae Pubescentis 15 g, parasitic Loranthus 15 g, glossy privet fruit 15 g, Semen Cuscutae 15 g, Angelica sinensis 15 g, Eucommia ulmoides 15 g, Barbary wolfberry fruit 15 g, Radix Sileris 15 g, Semen Psoraleae 15 g, Achyranthes root 15 g, peach seed 10 g, flowers carthami 10 g, Rhizoma Chuanxiong 10 g, herba Lycopi 10 g, liquorice 6 g, Asarum 3 gDecoctionHospital preparation
Liu 2011 [43]Zhengqing Fengtongning tabletSinomenine 60 mgTabletSFDA approval number: Z20010174
Liu 2016 [41]Jingu Tongning capsuleRheum officinale, woodlouse, olibanum, myrrh, Angelica sinensis, flowers carthami, Radix Paeoniae Alba, Fructus forsythiae, Fructus gardeniae, borneolCapsuleHenan FDA approval number: Z 204090031
Liu 2017 [42]Shujin decoctionAstragalus 15 g, Epimedium 15 g, cornu Cervi degelatinatum 15 g, Rhizoma Chuanxiong 15 g, Radix Rehmanniae Praeparata 15 g, Radix Angelicae Pubescentis 15 g, Radix Aconiti Lateralis Preparata 10 g, Lycopodium clavatum 10 g, Rhizoma seu Radix Notopterygii 10 g, Barbary wolfberry fruit 10 g, Angelica sinensis 10 g, Radix Sileris 10 g, Kadsura pepper stem 8 g, Radix Paeoniae Alba 30 g, Fructus cnidii 12 g, Caulis Spatholobi 20 g, Elecampane 8 g, liquorice 8 gDecoctionHospital preparation
Lu 2016 [44]Lujiao Zhuanggu capsuleCornu Cervi Degelatinatum, Fructus psoraleae, Astragalus, wolfberry, Rhizoma Chuanxiong, Rheum officinale, Radix DipsaciCapsuleGuizhou EDA approval number: Z20120003
Luo 2019 [45]Zhengqing Fengtongning tabletSinomenine 60 mgTabletSFDA approval number: Z20010174
Ma 2009 [48]Huoxue Tongluo decoctionPeach seed 10 g, flowers carthami 12 g, Rhizoma Chuanxiong 10 g, Angelica sinensis 12 g, root of common peony 10 g, Achyranthes root 12 g, parasitic Loranthus 15 g, Eucommia ulmoides 12g, Radix Clematidis 12 gDecoctionHospital preparation
Ma 2018 [46]Duhuo Jisheng decoctionRadix angelicae pubescentis 15 g, Parasitic loranthus 15 g, glossy privet fruit 15 g, Semen cuscutae 15 g, Angelica sinensis 15 g, Eucommia ulmoides 15 g, Barbary Wolfberry fruit 15 g, Radix Sileris 15 g, semen psoraleae 15 g, Achyranthes root 15 g, peach seed 10 g, flowers carthami 10 g, Rhizoma Chuanxiong 10 g, Herba Lycopi 10 g, liquorice 6 g, Asarum 3 gDecoctionHospital preparation
Ma 2019 [47]Bushen Yiqi Huayu Jiedu decoctionAstragalus 15 g, Fructus psoraleae 15 g, herba Cistanche 15 g, Radix Codonopsis 12 g, Rhizoma Chuanxiong 9 g, Salviae miltiorrhizae 9 g, synthetic musk 0.03 gDecoctionHospital preparation
Mo 2018 [49]Kangguzhi Zengsheng capsuleRadix Rehmanniae Praeparata, desert Cistanche, Rhizoma Cibotii, glossy privet fruit, Epimedium, Caulis Spatholobi, Radish seed, Rhizoma Drynariae, Achyranthes rootCapsuleSFDA approval number: Z10980006
Pan 2017 [22]Longbie capsuleMorinda officinalis, Rhizoma Curculiginis, Semen Cuscutae, Scorpio, centipede, Agkistrodon, woodlouse, Salviae miltiorrhizae, Radix Aconiti PreparataCapsuleGuangdong FDA approval number: Z20071030
Qian 2019 [51]Yishen Quyu decoctionRhizoma Chuanxiong 18 g, Chinese angelica 18 g, root of Achyranthes bidentata 18 g, Rhizoma Drynariae 18 g, Rhizoma Cibotii 15 g, Epimedium 15 g, pubescent angelica root 12 g, Eucommia ulmoides 12 g, Radix Dipsaci 12 gDecoctionHospital preparation
Ren 2016 [53]Yishen Quyu decoctionRhizoma Chuanxiong 18 g, Angelica sinensis 18 g, Achyranthes root 18 g, Rhizoma Drynariae 18 g, Rhizoma Cibotii 15 g, Epimedium 15 g, Radix Angelicae Pubescentis 12 g, Morinda officinalis 12 g, Eucommia ulmoides 12 g, Radix Dipsaci 12 gDecoctionHospital preparation
Ren 2018 [52]Duhuo Jisheng decoctionRadix Angelicae Pubescentis 15 g, parasitic Loranthus 15 g, glossy privet fruit 15 g, Semen Cuscutae 15 g, Angelica sinensis 15 g, Eucommia ulmoides 15 g, Barbary wolfberry fruit 15 g, Radix Sileris 15 g, Semen Psoraleae 15 g, Achyranthes root 15 g, peach seed 10 g, flowers carthami 10 g, Rhizoma Chuanxiong 10 g, herba Lycopi 10 g, liquorice 6 g, Asarum 3 gDecoctionHospital preparation
Rong 2017 [54]Duhuo Jisheng decoctionRadix Angelicae Pubescentis 15 g, parasitic Loranthus 15 g, glossy privet fruit 15 g, Semen Cuscutae 15 g, Angelica sinensis 15 g, Eucommia ulmoides 15 g, Barbary wolfberry fruit 15 g, Radix Sileris 15 g, Semen Psoraleae 15 g, Achyranthes root 15 g, peach seed 10 g, flowers carthami 10 g, Rhizoma Chuanxiong 10 g, herba Lycopi 10 g, liquorice 6 g, Asarum 3 gDecoctionHospital preparation
Shi 2019 [55]Duhuo Jisheng decoctionRadix Angelicae Pubescentis 15 g, parasitic Loranthus 15 g, glossy privet fruit 15 g, Semen Cuscutae 15 g, Angelica sinensis 15 g, Eucommia ulmoides 15 g, Barbary wolfberry fruit 15 g, Radix Sileris 15 g, Semen Psoraleae 15 g, Achyranthes root 15 g, peach seed 10 g, flowers carthami 10 g, Rhizoma Chuanxiong 10 g, herba Lycopi 10 g, liquorice 6 g, Asarum 3 gDecoctionHospital preparation
Song 2017 [56]Duhuo Jisheng decoctionRadix Angelicae Pubescentis 15 g, parasitic Loranthus 15 g, glossy privet fruit 15 g, Semen Cuscutae 15 g, Angelica sinensis 15 g, Eucommia ulmoides 15 g, Barbary wolfberry fruit 15 g, Radix Sileris 15 g, Semen Psoraleae 15 g, Achyranthes root 15 g, peach seed 10 g, flowers carthami 10 g, Rhizoma Chuanxiong 10 g, herba Lycopi 10 g, liquorice 6 g, Asarum 3 gDecoctionHospital preparation
Sun 2018 [57]Qinbi decoctionChinese starjasmine stem 12 g, Caulis Sinomenii 12 g, honeysuckle stem 12 g, Semen Coicis 21 g, Tuckahoe 15 g, Achyranthes root 12 g, parasitic Loranthus 15 g, Radix Stephaniae Tetrandrae 9 g, Cortex Phellodendri 9 g, root of common peony 9 g, Radix Clematidis 9 g, parasitic Loranthus 9 g, Rhizoma Corydalis 6 g, liquorice 6 gDecoctionHospital preparation
Tan 2014 [58]Huangqi Biejia pillGinseng, Cortex Cinnamomi, Radix Rehmanniae Recen, Pinellia ternata, Radix Asteris, Rhizoma Anemarrhenae, Astragalus, liquorice, Radix Asparagi, Carapax Trionycis, Gentiana macrophylla, white poria, Cortex Lycii Radicis, Radix BupleuriPillHospital preparation
Tang 2012 [59]Jiedu Yishen pillRadix Cynanchi Panicullati 120 g, Achyranthes root 80 g, Eucommia ulmoides 80 g, Rhizoma Chuanxiong 80 g, woodlouse 40 g, Cortex Phellodendri 40 gPillHospital preparation
Wang 2013 [60]Fufang Xiatian Wu pillCorydalis amabilis, Radix Aconiti Kusnezoffi Preparata, herba Siegesbeckiae, Cissus assamica, Caulis Spatholobi, Paederia scandens, Radix Clematidis, Aristolochia fangchi, Cortex Acanthopanacis, Rhizoma seu Radix Notopterygii, Gentiana macrophylla, Agkistrodon, herba ephedraPillSFDA approval number: Z20003105
Wang 2019 [61]Taoren Xikang pillPeach seed, flowers carthami, Angelica sinensis, Radix Rehmanniae Praeparata, Rhizoma Chuanxiong, Radix Paeoniae Alba, Radix Angelicae Pubescentis, Radix Sileris, parasitic Loranthus, Achyranthes root, Asarum, olibanum, myrrhPillHenan FDA approval number: Z20120243
Wen 2016 [62]Duhuo Jisheng decoctionRadix Angelicae Pubescentis 15 g, parasitic Loranthus 15 g, glossy privet fruit 15 g, Semen Cuscutae 15 g, Angelica sinensis 15 g, Eucommia ulmoides 15 g, Barbary wolfberry fruit 15 g, Radix Sileris 15 g, Semen Psoraleae 15 g, Achyranthes root 15 g, peach seed 10 g, flowers carthami 10 g, Rhizoma Chuanxiong 10 g, herba Lycopi 10 g, liquorice 6 g, Asarum 3 gDecoctionHospital preparation
Wu 2012 [65]Zhuanggu Tongbi pillRadix Rehmanniae Praeparata 12 g, Eucommia ulmoides 15 g, herba Pyrolae 30 g, pulp of dogwood fruit 15 g, Rhizoma Drynariae 15 g, Radix Clematidis 30 g, Radix Dipsaci 15 g, Achyranthes root 15 g, garden balsam stem 15 g, Chinese Polyphaga 9 g, Tuckahoe 12 g, Radix Aconiti Preparata 9 g, Fructus psoraleae 15 g, parasitic Loranthus 15 gPillHospital preparation
Wu 2018 [63]Bushen Huoxue decoctionRadix Rehmanniae Praeparata 15 g, Epimedium 15 g, Semen Cuscutae 15 g, Angelica sinensis 10 g, Salviae miltiorrhizae 10 g, Achyranthes root 10 g, Eucommia ulmoides 10 g, Radix Dipsaci 10 g, Radix Codonopsis 15 g, Rhizoma Atractylodis macrocephalae 15 g, liquorice 6 gDecoctionHospital preparation
Wu 2018 [64]Sanqi Xuejie capsuleNotoginseng root Radix, Resina DraconisCapsuleHospital preparation
Xia 2017 [66]Jinwu Gutong capsuleRhizoma Cibotii, Epimedium, Radix Clematidis, Zaocys dhumnade, Achyranthes root, Chinese quince, root of kudzu vine, Radix Curcumae Longae, Fructus psoraleae, Radix CampanumoeaeCapsuleSFDA approval number: Z20043621
Yang 2016 [67]Jiawei Simiao PulvisCortex Phellodendri 5 g, Rhizoma Atractylodis 10 g, Semen Coicis 10 g, Achyranthes root 10 g, Radix Stephaniae Tetrandrae 10 g, Fructus forsythiae 10 g, Radix Sophorae Flavescentis 10 g, Chinese quince 10 g, Gentiana macrophylla 10 g, Radix Rehmanniae Recen 15 g, honeysuckle stem 15 gPulvisHospital preparation
Yang 2019 [68]Duhuo Jisheng decoctionRadix Angelicae Pubescentis 15 g, parasitic Loranthus 15 g, glossy privet fruit 15 g, Semen Cuscutae 15 g, Angelica sinensis 15 g, Eucommia ulmoides 15 g, Barbary wolfberry fruit 15 g, Radix Sileris 15 g, Semen Psoraleae 15 g, Achyranthes root 15 g, peach seed 10 g, flowers carthami 10 g, Rhizoma Chuanxiong 10 g, herba Lycopi 10 g, liquorice 6 g, Asarum 3 gDecoctionHospital preparation
Yao 2013 [69]Duhuo Jisheng decoctionRadix Angelicae Pubescentis 15 g, parasitic Loranthus 15 g, glossy privet fruit 15 g, Semen Cuscutae 15 g, Angelica sinensis 15 g, Eucommia ulmoides 15 g, Barbary wolfberry fruit 15 g, Radix Sileris 15 g, Semen Psoraleae 15 g, Achyranthes root 15 g, peach seed 10 g, flowers carthami 10 g, Rhizoma Chuanxiong 10 g, herba Lycopi 10 g, liquorice 6 g, Asarum 3 gDecoctionHospital preparation
Yi 2017 [70]Bushen Huoxue decoctionRadix Rehmanniae Praeparata 15 g, Epimedium 15 g, Semen Cuscutae 15 g, Angelica sinensis 10 g, Salviae miltiorrhizae 10 g, Achyranthes root 10 g, Eucommia ulmoides 10 g, Radix Dipsaci 10 g, Radix Codonopsis 15 g, Rhizoma Atractylodis macrocephalae 15 g, liquorice 6 gDecoctionHospital preparation
Yi 2017 [71]Qiangjin Zhuanggu decoctionSemen Cuscutae 15 g, Rhizoma Curculiginis 20 g, Morinda officinalis 10 g, Radix Rehmanniae Praeparata 15 g, parasitic Loranthus 10 g, Radix Aconiti Preparata 9 g, Scorpio 4 g, centipede 4 g, Radix Clematidis 15 g, Lycopodium clavatum 15 g, Caulis Spatholobi 15 g, Rhizoma Chuanxiong 15 g, Ramulus mori 10 g, Radix Sileris 10 g, Tribulus terrestris 15 g, liquorice 10 gDecoctionHospital preparation
Yu 2010 [72]Duhuo Jisheng decoctionRadix Angelicae Pubescentis 15 g, parasitic Loranthus 15 g, glossy privet fruit 15 g, Semen Cuscutae 15 g, Angelica sinensis 15 g, Eucommia ulmoides 15 g, Barbary wolfberry fruit 15 g, Radix Sileris 15 g, Semen Psoraleae 15 g, Achyranthes root 15 g, peach seed 10 g, flowers carthami 10 g, Rhizoma Chuanxiong 10 g, herba Lycopi 10 g, liquorice 6 g, Asarum 3 gDecoctionHospital preparation
Yuan 2017 [73]Bushen Huoxue decoctionRadix Rehmanniae Praeparata 15 g, Epimedium 15 g, Semen Cuscutae 15 g, Angelica sinensis 10 g, Salviae miltiorrhizae 10 g, Achyranthes root 10 g, Eucommia ulmoides 10 g, Radix Dipsaci 10 g, Radix Codonopsis 15 g, Rhizoma Atractylodis macrocephalae 15 g, liquorice 6 gDecoctionHospital preparation
Zhang 2016 [74]Jinwu Gutong capsuleRhizoma Cibotii, Epimedium, Radix Clematidis, Zaocys dhumnade, Achyranthes root, Chinese quince, root of kudzu vine, Radix Curcumae Longae, Fructus psoraleae, Radix CampanumoeaeCapsuleSFDA approval number: Z20043621
Zhang 2017 [77]Fugui Gutong capsuleRadix Aconiti Lateralis Preparata, Radix Aconiti Preparata, Cortex Cinnamomi, Codonopsis pilosula, Angelica sinensis, Radix Paeoniae Alba, Epimedium, olibanumCapsuleSFDA approval number: Z19990026
Zhang 2018 [76]Qianggu capsuleRhizoma Drynariae 0.25 gCapsuleSFDA approval number: Z20030007
Zhang 2019 [75]Duhuo Jisheng decoctionRadix Angelicae Pubescentis 15 g, parasitic Loranthus 15 g, glossy privet fruit 15 g, Semen Cuscutae 15 g, Angelica sinensis 15 g, Eucommia ulmoides 15 g, Barbary wolfberry fruit 15 g, Radix Sileris 15 g, Semen Psoraleae 15 g, Achyranthes root 15 g, peach seed 10 g, flowers carthami 10 g, Rhizoma Chuanxiong 10 g, herba Lycopi 10 g, liquorice 6 g, Asarum 3 gDecoctionHospital preparation
Zheng 2014 [78]Zhengqing Fengtongning tabletSinomenine 60 mgTabletSFDA approval number: Z20010174
Zheng 2019 [79]Bushen Huoxue decoctionRadix Rehmanniae Praeparata 15 g, Epimedium 15 g, Semen Cuscutae 15 g, Angelica sinensis 10 g, Salviae miltiorrhizae 10 g, Achyranthes root 10 g, Eucommia ulmoides 10 g, Radix Dipsaci 10 g, Radix Codonopsis 15 g, Rhizoma Atractylodis macrocephalae 15 g, liquorice 6 gDecoctionHospital preparation
Zhong 2017 [80]Shentong Zhuyu decoctionAngelica sinensis 15 g, Rhizoma Chuanxiong 15 g, Achyranthes root 15 g, peach seed 12 g, flowers carthami 12 g, Gentiana macrophylla 12 g, Rhizoma seu Radix Notopterygii 12 g, Rhizoma Cyperi 9 g, myrrh 9 g, earthworm 9 g, Trogopterus Dung 6 g, liquorice 6 gDecoctionHospital preparation
Zhou 2012 [81]Shufu Jiangu decoctionRadix Aconiti Lateralis Preparata 10 g, Radix Rehmanniae Praeparata 20 g, Rhizoma Drynariae 10 g, Radix Dipsaci 15 g, Radix Angelicae Pubescentis 10 g, Achyranthes root 15 g, Radix Clematidis 10 g, Salviae miltiorrhizae 15 g, pangolin scales 10 g, Scorpio 3 g, Ramulus mori 15 g, liquorice 6 gDecoctionHospital preparation
Zhu 2013 [82]Zhengqing Fengtongning tabletSinomenine 60 mgTabletSFDA approval number: Z20010174
Zhuo 2019 [83]Rendong Bixie decoctionHoneysuckle stem 30 g, yam rhizome 15 g, Radix Clematidis 12 g, bark of Himalayan coralbean 15 g, root of common peony 12 g, Radix Gentianae Macrophyllae 15 g, herba Siegesbeckiae 15 g, loofah sponge 20 g, Ramulus mori 30 gDecoctionHospital preparation

SFDA: State Food and Drug Administration; FDA: Food and Drug Administration.